兽医公共卫生学系

    兽医公共卫生学系

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    • 王琳教授
    • 性别:女
    • 职称:教授
    • 硕导/博导:博导
    • 学科专业:兽医药理学
    • 最高学位:博士
    • 研究方向:细菌感染疾病药物靶标发现、新药筛选及相关剂型研究;新兽药开发及检测分析
    • 最高学历:研究生
    • 邮箱:wanglin1020@jlu.edu.cn

    讲授课程

    药理学,兽药制剂学,药剂学,兽医药理学与毒理学,分子药理学

    教育经历

    2003.08-2007.06,沈阳药科大学,药物制剂,学士学位

    2007.08-2012.06,中国人民解放军第二军医大学,药理学,博士学位

    工作经历

    2012.12-2016.09,suncitygroup太阳集团,人兽共患病研究所,讲师

    2016.09-2022.09,suncitygroup太阳集团,人兽共患病研究所,副教授

    2022.09-至今,suncitygroup太阳集团,人兽共患病研究所,教授

    科研项目

    1.横向课题,多穗石柯提取物口服液的新兽药研制,3R1205874206,2020/10-2025/10,150.00万元,在研,负责人。

    2.横向课题,金霉素预混剂羊病原菌药敏试验和最佳适应症筛选,3R2220064206,2021/12-2022/03,35.00万元,已结题,负责人。

    3.suncitygroup太阳集团优秀青年教师培养计划,2018/01-2021/12,18万

    4.国家自然科学基金青年基金项目,No. 31502117,槲皮素对金黄色葡萄球菌凝固酶的抑制作用及机制,2016/01-2018/12,20万,已结题,负责人。

    5.中国博士后科学基金特别资助,2015T80309,金黄色葡萄球菌分选酶SortaseB抑制剂筛选及机制研究,2015/05-2016/10,15万元,已结题,负责人。

    6.中国博士后面上资助,2014M561301,咖啡酸对金葡菌分选酶SortaseA的抑制作用及机制,2014/09-2016/10,5万元,已结题,负责人。

    7.吉林省科技发展计划科技创新人才培育计划优秀青年人才基金项目,20180520043JH,绵马贯众素通过抑制vWbp蛋白治疗金葡菌感染的药效学评价及机制研究,2018/01-2019/12,10万,已结题,负责人。

    学术论文

    1.Shi L, Tianqi F, Zhang C, Deng X, Zhou Y, Wang J*,Wang L*. High-protein compound yogurt with quinoa improved clinical features and metabolism of high-fat diet-induced nonalcoholic fatty liver disease in mice. J Dairy Sci. 2023.106(8):5309-5327.

    2.Liu M#, Lv Q#, Xu J, Liu B, Zhou Y, Zhang S, Shen X*,Wang L*. Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro. Biochem Pharmacol. 2023. 209:115447.

    3.Guan S#, Zhong L#, Yu H, Wang L, Jin Y, Liu J, Xiang H, Yu H*,Wang L*, Wang D*. Molecular docking and proteomics reveals the synergistic antibacterial mechanism of theaflavin with β-lactam antibiotics against MRSA. Front Microbiol. 2022. 13:993430.

    4.Guan S#, Yu H#, Xiang H, Wang L, Liu J, Wu A, Zheng J, Dong H*,Wang L*,Wang D*. WYBQ-4: a New Bactericidal Agent against Methicillin-Resistant Staphylococcus aureus. Microbiol Spectr. 2022. 10(5):e0054722.

    5.Li S, Xu X, Wei L,Wang L*, Lv Q*. Acacetin Alleviates Listeria monocytogenes Virulence Both In Vitro and In Vivo via the Inhibition of Listeriolysin O. Foodborne Pathog Dis. 2022. 19(2):115-125.

    6.Jin Y#, Yang P#, Wang L#, Gao Z, Lv J, Cui Z, Wang T, Wang D*,Wang L*. Galangin as a direct inhibitor of vWbp protects mice from Staphylococcus aureus-induced pneumonia. J Cell Mol Med. 2022. 26(3):828-839.

    7.Wang L#, Li Q#, Li J, Jing S, Jin Y, Yang L, Yu H, Wang D, Wang T,Wang L*. Eriodictyol as a Potential Candidate Inhibitor of Sortase A Protects Mice From Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia. Front Microbiol. 2021. 12:635710.

    8.Wang L,Li B, Si X, Liu X, Deng X, Niu X, Jin Y, Wang D, Wang J.Quercetin protects rats from catheter‐related Staphylococcus aureus infections by inhibiting coagulase activity.J Cell Mol Med. 2019.

    9.Mu D#, Luan Y#,Wang L#, Gao Z, Yang P, Jing S, Wang Y, Xiang H, Wang T*, Wang D*. The combination of salvianolic acid A with latamoxef completely protects mice against lethal pneumonia caused by methicillin-resistant Staphylococcus aureus. Emerg Microbes Infect. 2020. 9(1):169-179.

    10.Li B, Jin Y, Xiang H, Mu D, Yang P, Li X, Zhong L, Cao J, Xu D, Gong Q, Wang T,Wang L*, Wang D*. An Inhibitory effect of Dryocrassin ABBA on Staphylococcus aureus vWbp that Protects Mice from Pneumonia. Front Microbiol. 2019. 10:7.

    11.Zhong X#, Xiang H#, Wang T#, Zhong L, Ming D, Nie L, Cao F, Li B, Cao J, Mu D, Ruan K,Wang L*, Wang D*. A novel inhibitor of the new antibiotic resistance protein OptrA. Chem Biol Drug Des. 2018 . 92(2):1458-67.

    12.Ming D#, Wang D#, Cao F, Xiang H, Mu D, Cao J, Li B, Zhong L, Dong X, Zhong X,Wang L*, Wang T*. Kaempferol Inhibits the Primary Attachment Phase of Biofilm Formation in Staphylococcus aureus. Front Microbiol. 2017. 8:2263.

    13.Zhao X, Liu B, Liu S,Wang L*, Wang J*. Anticytotoxin Effects of Amentoflavone to Pneumolysin. Biol Pharm Bull. 2017. 40(1):61-7.

    14.Bi C, Dong X, Zhong X, Cai H, Wang D*,Wang L*. Acacetin Protects Mice from Staphylococcus aureus Bloodstream Infection by Inhibiting the Activity of Sortase A. Molecules. 2016. 21(10).

    15.Bi C#,Wang L#, Niu X, Cai H, Zhong X, Deng X, Wang T*, Wang D*. The use of chlorogenic acid and its analogues as inhibitors: an investigation of the inhibition of sortase A of Staphylococcus aureus using molecular docking and dynamic simulation. Biotechnol Lett. 2016. 38(8):1341-7.

    16.Wang L#, Bi C#, Cai H, Liu B, Zhong X, Deng X, Wang T, Xiang H, Niu X*, Wang D*. The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition. Front Microbiol. 2015. 6:1031.

    17.Wang L#, Bi C#, Wang T, Xiang H, Chen F, Hu J, Liu B, Cai H, Zhong X, Deng X, Wang D*. A coagulase-negative and non-haemolytic strain of Staphylococcus aureus for investigating the roles of SrtA in a murine model of bloodstream infection. Pathog Dis. 2015 Aug;73(6):ftv042.

    著作教材

    1.《分子生物学实验原理与技术》,科学出版社,2015,副主编。

    2.《人兽共患病学》,科学出版社,2015,参编。

    获奖情况

    获2017suncitygroup太阳集团优秀青年教师培养计划

    2014,2016年青年教师讲课比赛suncitygroup太阳集团三等奖,2019年一等奖

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