临床兽医学系

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  • 宋玉祥副教授
  • 性别:男
  • 职称:教授
  • 硕导/博导:博导
  • 学科专业:临床兽医学
  • 最高学位:博士
  • 研究方向:奶牛代谢与免疫;兽医影像新技术;肠道菌群
  • 最高学历:研究生
  • 邮箱:songyuxiang@jlu.edu.cn;

讲授课程

本科生:兽医影像学、兽医临床病理学

硕士生:兽医临床技术、动物临床疾病诊疗、兽医临床诊疗新技术

教育经历

2014.10-2019.02,法国巴黎萨克雷大学,医学,博士学位

2011.09-2014.06,suncitygroup太阳集团,临床兽医学,硕士学位

2007.09-2011.06,湖南农业大学,大学本科

工作经历

2022.09-至今,suncitygroup太阳集团,suncitygroup太阳集团,副教授

2020.01-至今,suncitygroup太阳集团,suncitygroup太阳集团,博士后

2019.07-2022.09,suncitygroup太阳集团,suncitygroup太阳集团,讲师

科研项目

1.国家自然科学基金委员会,青年科学基金项目,32102737,β-羟丁酸调控酮病奶牛中性粒细胞凋亡的分子机制,2022.01-2024.12,30万,在研,主持

2.中国博士后科学基金会,博士后面上项目,2021M701394,PKCα-RhoA/Rac1信号通路调控β-羟丁酸抑制奶牛中中国博士后科学基金会性粒细胞迁移机制,2021.12-2023.12,8万,在研,主持

3.吉林省教育厅,吉林省教委科研基金项目,JJKH20211135KJ,SARA奶牛高组胺血症对中性粒细胞粘附的影响及其分子机制,2021.01-2022.12,2.5万,结题,主持

4.suncitygroup太阳集团,发展规划处,JLUXKJC2021QZ15,基于微流控芯片研究PKCα信号通路介导β-羟丁酸损害奶牛中性粒细胞迁移机制,2022.01-2023.12,5万,在研,主持

5.横向课题,防治犊牛腹泻的合生元应用,2021.12-2023.12,8万,在研,主持

学术论文

1.Y Yang, S Jiang, J Yang, X Feng, C Wang, W Gao, X Du, L Lei, G Liu,Y X Song*, X Li*. 2023. BHB impairs the directionality of migrating neutrophil through inhibiting the autophagy-dependent degradation of Cdc42 and Rac1 in ketotic cows. Journal of Dairy Science.中科院一区,TOP期刊

2.Y X Song, J J Loor, C Li, Y Liang, N Li, X Shu, Y Yang, X Feng, X Du, Z Wang, G Liu, and X Li. 2021. Enhanced mitochondrial dysfunction and oxidative stress in the mammary gland of cows with clinical ketosis. Journal of Dairy Science 104(6):6909-6918.中科院一区,TOP期刊

3.K X Wang, Z N Sun, Y F Li, M C Liu, J J Loor, Q M Jiang, G W Liu, Z Wang,Y X Song*, and X W Li*. 2022. Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Journal of Dairy Science 105(9):7600-7614.中科院一区,TOP期刊

4.Y X Song, K X Wang, J J Loor, Q M Jiang, Y C Yang, S Jiang, S Y Liu, J Y He, X C Feng, X L Du, L Lei, W W Gao, G W Liu, and X W Li. 2022. beta-Hydroxybutyrate inhibits apoptosis in bovine neutrophils through activating ERK1/2 and AKT signaling pathways. Journal of Dairy Science 105(4):3477-3489.中科院一区,TOP期刊

5.Y X Song#, Y C Yang#, W Zeng, J J Loor, Q M Jiang, Z C Peng, Y F Li, S Jiang, X C Feng, X L Du, X W Li*, and G W Liu*. 2022. beta-Hydroxybutyrate impairs neutrophil migration distance through activation of a protein kinase C and myosin light chain 2 signaling pathway in ketotic cows. Journal of Dairy Science 105(1):761-771.中科院一区,TOP期刊

6.Y X Song#, S Jiang#, C Li, J J Loor, Q Jiang, Y Yang, X Feng, S Liu, J He, K Wang, Y Li, C Zhang, X Du, Z Wang, X Li, and G Liu. 2022a. Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Journal of Dairy Science 105(3):2473-2486.中科院一区,TOP期刊

7.Z Shi#,Y X Song#, X Gao#, J J Loor, A Aboragah, H Yu, Z Fang, Y Zhu, X Du, X Li, W Gao*, and G Liu*. 2021. Disruption of endoplasmic reticulum homeostasis exacerbates liver injury in clinically ketotic cows. Journal of Dairy Science 104(8):9130-9141.中科院一区,TOP期刊

8.J Y He#, K X Wang#, M C Liu, W Zeng, D Li, Z Majigsuren, T Batbaatar, Y F Li, S Y Liu, X L Du, L Lei,Y X Song*, and G W Liu*. 2023. beta-hydroxybutyrate enhances bovine neutrophil adhesion by inhibiting autophagy. Front Immunol 13:1096813. TOP期刊

9.X C Feng#,Y X Song#, Z A Sun, J J Loor, Q M Jiang, C Gao, S Y Liu, Y C Yang, X L Du, Z Wang, G W Liu*, and X W Li*. 2022. Palmitic acid hinders extracellular traps of neutrophil from postpartum dairy cow in vitro. Journal of Dairy Science 105(10):8286-8297.中科院一区,TOP期刊

10.S Y Liu#, X B Li#, X H Zhou, J J Loor, Q M Jiang, X C Feng, Y C Yang, L Lei, X L Du, X W Li, W Zhe,Y X Song*, and G W Liu*. 2022. beta-Hydroxybutyrate impairs the release of bovine neutrophil extracellular traps through inhibiting phosphoinositide 3-kinase-mediated nicotinamide adenine dinucleotide phosphate oxidase reactive oxygen species production. Journal of Dairy Science 105(4):3405-3415.中科院一区,TOP期刊

11.Y X Song, J J Loor, C Zhao, D Huang, X Du, X Li, Z Wang, G Liu, and X Li. 2020. Potential hemo-biological identification markers to the left displaced abomasum in dairy cows. Bmc Veterinary Research 16(1):470.

12.Y X Song#, N Li#, J Gu, S Fu, Z Peng, C Zhao, Y Zhang, X Li, Z Wang, X Li*, and G Liu*. 2016. beta-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway. Journal of Dairy Science 99(11):9184-9198.中科院一区,TOP期刊

13.Y X Song#, X Li#, Y Li, N Li, X Shi, H Ding, Y Zhang, X Li*, G Liu*, and Z Wang. 2014. Non-esterified fatty acids activate the ROS-p38-p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro. Apoptosis 19(6):984-997.

获奖情况

1.省部级学术荣誉

(1)刘国文、李心慰、李小兵、王哲、杜希良、宋玉祥,奶牛酮病肝脂代谢紊乱所致肝损伤的分子机制,吉林省科技厅,吉林省科学技术奖,自然科学一等奖,2020

(2)宋玉祥、杨宇宸、姜尚、王可心、李云飞,SARA奶牛高组胺血症对中性粒细胞粘附的影响及其分子机制,吉林省教育厅,优秀结项课题,2022

(3)Yuxiang Song, Na Li, Jingmin Gu, Shoupeng Fu, Zhicheng Peng, Chenxu Zhao, Yuming Zhang, Xiaobing Li, Zhe Wang,Xinwei Li, Guowen Liu, β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway,美国乳业协会,高影响力论文奖,一等,2019

2.国家级大赛获奖指导老师

(1)李聪宜、韩胜男、郑洋、刘国文、宋玉祥,临床酮病奶牛乳腺线粒体功能障碍和氧化应激增强,全国老员工生命科学竞赛委员会,优秀指导教师,二等奖,2021

(2)李聪宜、韩胜男、郑洋、宋玉祥,游离脂肪酸通过诱导亚临床酮病奶牛中性粒细胞ROS的产生促进脱颗粒作用,全国老员工生命科学竞赛委员会,优秀指导教师,三等奖,2022

(3)孙贞爱、林鼎越、高梦晗、陈佳悦、郑捷、宋玉祥,“牛康乐”-围产期奶牛免疫功能检测技术,第八届中国国际“互联网+”老员工创新创业大赛,优秀指导教师,suncitygroup太阳集团金奖,2022

社会兼职

1.中国畜牧兽医学会兽医内科与临床诊疗学分会理事

2.Frontiers in immonology、Frontiers in Molecular Biosciences、Oxidative Medicine and Cellular Longevity等杂志审稿人

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