预防兽医学系

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  • 李娜教授
  • 性别:女
  • 职称:教授
  • 硕导/博导:博导
  • 学科专业:预防兽医学
  • 最高学位:博士
  • 研究方向:微生物学与免疫学:重要人兽共患病原菌的诊断、免疫病理机制、抗感染机制及防治技术
  • 最高学历:研究生
  • 邮箱:vetlina2013@126.com

简介

suncitygroup太阳集团唐敖庆领军教授,博士生导师,国家级青年人才计划入选者。荣获荷兰拉丁文学荣誉学位(Cum Laude,全国授予比例低于5%),欧洲“DIRK BARTZ PRIZEFOR VISUAL COMPUTING IN MEDICINE”一等奖(2019)和中国商业联合会科学技术奖三等奖(2023)。相关成果以第一/通讯作者在Nature Immunology(封面文章)、American Journal of Respiratory and Critical Care MedicineJournal of Experimental Medicine(封面文章)等杂志发表SCI论文20余篇。

讲授课程

本科生:兽医免疫学

硕士生:免疫学

教育经历

2007.9-2011.6,湖南农业大学,大学本科

2011.9-2014.6,suncitygroup太阳集团,预防兽医学,硕士学位

2014.10-2019.10,莱顿大学,医学,博士学位

工作经历

2020.12-至今,suncitygroup太阳集团教授

科研项目

1.国家自然科学基金优秀青年科学基金项目(海外),2022/01-2024/12,300万元,主持

2.suncitygroup太阳集团高层次人才引进科研启动基金,300万元,主持

3.国家自然科学基金青年基金项目,“Ly6C+Ly6G+双阳性CD4+T细胞调控肺脏中性粒细胞抗胸膜肺炎放线杆菌感染的作用及机制”,2022/01-2024/12,30万元,主持

suncitygroup太阳集团杰出青年培育计划,15万元,主持

学术论文

代表性论文

1.Li Jia#;Na Li#;Tamim R.M. Abdelaal;Nannan Guo;Marieke E. IJsselstein;Vincent van Unen;Ciska Lindelauf;Qinyue Jiang;Yanling Xiao;M. Fernanda Pascutti;Pieter S. Hiemstra;Frits Koning;Jan Stolk;P. Padmini S.J. Khedoe*; High-dimensional mass cytometry reveals emphysema-associated changes in the pulmonary immune system,American Journal of Respiratory and Critical Care Medicine, 2024.(IF:19.3,1区Top)

2.(封面文章)Na Li; Vincent van Unen; Tamim Abdelaal; Nannan Guo; Sofya A. Kasatskaya; Kristin Ladell; James E. McLaren; Evgeny S. Egorov; Mark Izraelson; Susana M. Chuva de Sousa Lopes; Thomas Höllt; Olga V Britanova; Jeroen Eggermont; Noel F.C.C. de Miranda; Dmitriy M. Chudakov; David A. Price; Boudewijn P.F. Lelieveldt; Frits Koning*; Memory CD4+ T cells are generated in the human fetal intestine,Nature Immunology, 2019, 20(3): 301-312.(IF:27.7,1区TOP,Nature Immunology新闻与观点”(news&views)同期专题报道,2019年Nature Reviews Immunology亮点文章之一)

3.(封面文章)Na Li#; Vincent van Unen#; Thomas Höllt; Allan Thompson; Jeroen van Bergen; Nicola Pezzotti; Elmar Eisemann; Anna Vilanova; Susana M.Chuva de Sousa Lopes; Boudewijn P.F.Lelieveldt; Frits Koning*; Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine,Journal of Experimental Medicine, 2018, 215(5): 1383-1396.(IF:15.3,1区TOP)

4.Jikun Mei#; Xuan Jiang#; Fengyang Li; Zengshuai Wu; Tong Wu; Junhui Zhu; Hexiang Jiang; Ziheng Li;Na Li*; Liancheng Lei*;Streptococcus suis serotype 2 collagenase-like protease promotes meningitis by increasing blood-brain barrier permeability,Journal of Integrative Agriculture, 2024.(IF:4.6,1区TOP)

5.Na Li; Junhui Zhu; Peiru Chen; Chuntong Bao; Jun Wang; Tamim Abdelaal; Dexi Chen; Sibo Zhu; Wenjing Wang; Jiangnan Mao; Brendon P. Scicluna; Frits Koning; Fengyang Li*; Liancheng Lei*; High-dimensional analysis reveals an immune atlas and novel neutrophil clusters in the lungs of model animals with Actinobacillus pleuropneumoniae-induced pneumonia,Veterinary Research, 2023, 54(1).(IF:3.7,1区TOP)

6.Tong Wu;Hexiang Jiang;Fengyang Li;Xuan Jiang;Jun Wang;Shaopeng Wei;Yi Sun; Yanyan Tian; Hong Chu;Yu Shi;Nan Zhang; Na Li*;Liancheng Lei*;O-acetyl-homoserine sulfhydrylase deficient Streptococcus suis serotype 2 strain SC19 becomes an avirulent strain and provides immune protection against homotype infection in mice.VeterinaryMicrobiology. 2024, 288:109943.(IF:2.4,1区)

7.JunWang;LinGan;FenyangLi;QinLi;TongWu;ZengshuaiWu;PeiruChen, Brendon P Scicluna,XinFeng,JinminGu,WenyuHan,NaLi*,LianchengLei*;Tracheal epithelial cell-exosome-derived MiR-21-5p inhibits alveolar macrophage pyroptosis to resist pulmonary bacterial infection through PIK3CD-autophagy pathway.Life Sciences,2024, 1;336:122340.(IF:5.2,2区TOP)

8.Xuan Jiang#; Fengyang Li#; Jikun Mei; Tong Wu; Junhui Zhu; Ziheng Li; Zengshuai Wu; Hexiang Jiang;Na Li*; Liancheng Lei*; Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice,Molecular Neurobiology, 2024,(IF:4.6,2区)

9.Zengshuai Wu#;Na Li#;Ziheng Li;Jianlong Wang;Mengmeng Liu;Mengzhu Qi;Shaopeng Wei;Tong Wu;Yu Guo;Junhui Zhu;Hexiang Jiang;Ruixue Xue;Changjiang Sun;Xin Feng;Jingmin Gu;Wenyu Han;Fengyang Li*;Liancheng Lei*. Development and application of an indirect ELISA and nested PCR for the epidemiological analysis of Klebsiella pneumoniae among pigs in China.Frontiers in Microbiology,2024 Jan 8;14:1329609.(IF:4.0,2区TOP)

10.Junhui Zhu;Rining Zhu;Hexiang Jiang;Ziheng Li;Xuan Jiang;Fengyang Li;Fuxian Zhang;Xin Feng;Jingmin Gu;Na Li*;Liancheng Lei*;Adh Promotes Actinobacillus pleuropneumoniae Survival in Porcine Alveolar Macrophages by Inhibiting CHAC2-Mediated Respiratory Burst and Inflammatory Cytokine Expression.Cells.2023,22;12(5):696.(IF:5.1,2区)

11.Peiru Chen; Chuntong Bao; Rining Zhu; Jun Wang; Junhui Zhu; Ziheng Li; Fengyang Li; Jingmin Gu; Xin Feng;Na Li*; Liancheng Lei*; IL-5 enhances the resistance of Actinobacillus pleuropneumoniae infection in mice through maintaining appropriate levels of lung M2, PMN-II and highly effective neutrophil extracellular traps,Veterinary Microbiology, 2022, 269:109438.(IF:2.4,1区)

12.Chuntong Bao#; Baijun Liu#; Rining Zhu; Jiameng Xiao; Ziheng Li; Hexiang Jiang; Beinan Wang; Langford Richard; Rui Fei;Na Li*; Liancheng Lei*; IFN-γ-/-mice resist Actinobacillus pleuropneumoniae infection by promoting early lung IL-18 release and PMN-I accumulation,Infection and Immunity, 2021,17;89(6):e00069-21.(IF:2.9)

13.Qiang Sun#;Na Li#; Li Jia; Wenfei Guo; Hexiang Jiang; Baijun Liu; Chuntong Bao; Mengmeng Liu; Jing Huang*; Liancheng Lei*; Ribosomal Protein SA-Positive Neutrophil Elicits Stronger Phagocytosis and Neutrophil Extracellular Trap Formation and Subdues Pro-Inflammatory Cytokine Secretion Against Streptococcus suis Serotype 2 Infection,Frontiers in Immunology, 2021,11:585399.(IF:5.1,2区)

14.Hexiang Jiang#; Tong Wu#; Jianan Liu; Xibing Yu; Hongtao Liu; Chuntong Bao; Mengmeng Liu; Yalu Ji; Xin Feng; Jingmin Gu; Wenyu Han;Na Li*; Liancheng Lei*; Caveolae/rafts protect human cerebral microvascular endothelial cells from Streptococcus suis serotype 2 α-enolase-mediated injury,Veterinary Microbiology, 2021, 254: 108981.(IF:2.4,1区)

15.Mengmeng Liu#;Na Li#; Wenfei Guo; Li Jia; Hexiang Jiang; Ziheng Li; Jun Wang; Xiaoguang Zhang; Rining Zhu; Chuntong Bao; Jing Huang*; Liancheng Lei*; RPSA distribution and expression in tissues and immune cells of pathogen-infected mice,Microbial Pathogenesis,2021, 152:104609.(IF:3.3)

16.Nannan Guo; Vincent van Unen; Marieke E. Ijsselsteijn; Laura F.Ouboter; Andrea E. van der Meulen; Susana M. Chuva de Sousa Lopes; Noel F. C. C. De Miranda; Frits Koning*;Na Li*; A 34-Marker Panel for Imaging Mass Cytometric Analysis of Human Snap-Frozen Tissue,Frontiers in Immunology, 2020, 11:1466.(IF:5.1,2区)

17.Na Li; Vincent van Unen; Nannan Guo; Tamim Abdelaal; Antonios Somarakis; Jeroen Eggermont; Ahmed Mahfouz; Susana M.Chuva de Sousa Lopes; Boudewijn P.F.Lelieveldt; Frits Koning*; Early-Life Compartmentalization of Immune Cells in Human Fetal Tissues Revealed by High-Dimensional Mass Cytometry,Frontiers inImmunology, 2019, 10: 1932.(IF:5.1,2区)

18.Yuxiang Song#;Na Li#;Jingmin Gu;Shoupeng Fu;Zhicheng Peng;Chenxu Zhao;Yuming Zhang;Xiaobing Li;Zhe Wang;Xinwei Li;Guowen Liu;β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway. 2016, 11, 9184-9198.Journal of Dairy Science(IF:3.7,1区TOP,ESI高被引文章)

19. Vincent van Unen;Na Li; Ilse Molendijk; Mine Temurhan; Thomas Höllt; Andrea E.van der Meulen-de Jong; Hein W.Verspaget; M. Luisa Mearin; Chris J.Mulder; Jeroen van Bergen; Boudewijn P.F.Lelieveldt;Frits Koning*; Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets,Immunity, 2016, 44(5): 1227-1239.(IF:25.5,1区Top)

获奖情况

1.荷兰拉丁文学位荣誉(Cum Laude,授予对象为业绩特别突出的博士毕业生,全国授予比例低于5%)

2.2019年欧洲“DIRK BARTZ PRIZE FOR VISUAL COMPUTING IN MEDICINE(医学计算机图像可视化德克巴茨奖)” 一等奖(排名4/8)

3. 2023年中国商业联合会科学技术奖三等奖,猪传染性胸膜肺炎综合防控技术研究与应用,

(排名2/15)

社会兼职

国际科学理事会中国委员会(ISC-CHINA)青年科学家专委会后备人员

中国畜牧兽医学会兽医公共卫生学分会理事

Animals and Zoonoses杂志青年编委,Frontiers in Immunology等杂志的审稿人

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